PQQ ——A Novel Human Essential Nutrient
What IS Pyrroloquinoline Quinone Disodium Salt (PQQ)?
PQQ (Pyrroloquinoline Quinone Disodium Salt) is a leading edge supplement that offers remarkable benefits for a versatile range of uses. This vitamin-like micronutrient can be found everywhere in nature — soil, plants, fruits, and animals. It is essential for a healthy mind, heart and body.
General Information of (PQQ)
Chemical Name: Pyrroloquinoline Quinone Disodium Salt (PQQ●Na2)
Molecular Formula: C14H4N2Na2O8
Pyrroloquinoline Quinone Disodium Salt Molecular Weight: 374.17
CAS Number: 122628-50-6
Appearance: Reddish brown powder
Melting Point: >300℃ (decomposed during the assay)
Solubility: Water-soluble (3g/L at 25℃)
Stability: Stable for at least 24 months.
Nutritional Importance of PQQ
Mice fed a chemically defined diet devoid of Pyrroloquinoline Quinone Disodium Salt (PQQ) grew poorly, failed toreproduce, and became osteolathyritic. Moreover, severely affected mice had friable skin, skin collagen that was readily extractable into neutral salt solutions, and decreased lysyl oxidase.The identification of functional defects in connective tissue and the growth retardation associated with PQQ deprivation suggest that PQQ plays a fundamental role as a growth factor or vitamin.
Physiologic Importance of PQQ
Pyrroloquinoline Quinone Disodium Salt (PQQ, methoxatin) is a dissociable cofactor for a number of bacterial dehydrogenases. The compound is unusual because of its ability to catalyze redox cycling reactions at a high rate of efficiency and it has the potential of catalyzing various carbonyl amine reactions as well. In methylotrophic bacteria, PQQ is derived from the condensation of L-tyrosine with L-glutamic acid. Whether or not PQQ serves as a cofactor in higher plants and animals remains controversial. Nevertheless, a strong case may be made that PQQ and related quinoids have nutritional and pharmacologic importance. In highly purified, chemically defined diets, PQQ stimulates animal growth. Furthermore, PQQ deprivation appears to impair connective tissue maturation, particularly when initiated in utero and throughout perinatal development.
Structure-Function Claims of PQQ
A novel antioxidant
PQQ protects human body and organs against aging.
PQQ is a large quinone molecule which has the ability to be a REDOX agent, capable of reducing oxidants (an antioxidant effect) and then being recycled by glutathione back into an active form.
It appears to be quite stable as it can undergo 20-thousand cycles before being used up, and it is novel since it associates with protein structures inside the cell
Protects and increases the functionality of existing mitochondria, and also promotes the generation of new mitochondria (Mitochondrial Biogenesis).
Increased mitochondria = increased energy production.
Stimulates production of Nerve Growth Factor (NGF)
NGF triggers growth of nerve cells to repair damaged nerves from stroke or other injury.
Benefits by Using PQQ
Cognitive Support
Prevents cognitive decline (memory loss, learning difficulty, etc.) due to age, stroke or neurodegenerative disorders. Protects and restores damaged brain and nerve cells.
Cardiovascular Support
Supports energy (ATP) metabolism by the mitochondria. Provides powerful antioxidant protection from damaging free radicals.
Liver Metabolism Support
Rescue acute and chromic liver injury caused by various factors.
Proven Benefits of PQQ (Human and In Vivo)
• PQQ Decreases Inflammation Biomarkers and Free Radicals
• Healthy humans who took 20mg of PQQ resulted in significant decreases chronic inflammation biomarkers of C-reactive protein (by 45% after 3 weeks) and IL-6.
• PQQ Creates New Mitochondria and Enhance Mitochondrial Function
• Stimulate mitochondrial biogenesis are linked to many health benefits such increased longevity, improved energy utilization, and protection from free radicals.
• By increasing cellular metabolism it favorably affects blood pressure, cholesterol and triglyceride breakdown, and the onset of obesity .
• Mice and rats fed diets lacking in pyrroloquinoline quinone (PQQ) have reduced mitochondrial content.
• PQQ Improves Memory and Reasoning
• A study with middle ages and elderly people found PQQ + CoQ10 led to a significant increase in performance in the Stroop test (measures reasoning) and reaction tests.
• PQQ Improves Brain Function By Increasing Nerve Growth Factor and Schwann Cells
• PQQ is Neuroprotective Against Alzheimer’s, Parkinson’s and Cognitive Injuries
• PQQ Improves Sleep, Mood, and Fatigue
• One open-label human study conducted with 20mg PQQ for 8 weeks in 17 persons with fatigue or sleep-impairing disorder noted that PQQ was able to significantly improve sleep quality, with improvements in sleep duration and quality appearing at the first testing period after 4 weeks. It also led to a decrease in the time it took to fall asleep but required 8 weeks to reach significance.
• PQQ Protects Brain and Heart Against Stroke
• PQQ administration reduces the size of damaged areas in animal models of acute brain stroke and heart attack.
• PQQ Decreases Insulin Resistance
• PQQ alleviates fat-induced insulin resistance by increasing mitochondrial biogenesis in muscle cells, similar to exercise
• PQQ Slows Down the Progression of Osteoarthritis by Inhibiting Nitric Oxide Production and Metalloproteinase Synthesis
• PQQ Improved Dry Skin Condition in Women
Where you can buy pyrroloquinoline quinone disodium salt (PQQ)?
With people becoming more and more aware of the benefits of pyrroloquinoline quinone disodium salt (PQQ, the demand for pyrroloquinoline quinone disodium salt (PQQ) supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the pyrroloquinoline quinone disodium salt (PQQ) supplements market, you must ensure that you are getting the highest-quality pyrroloquinoline quinone disodium salt (PQQ) powder. Sourcing good-quality material is the first step in ensuring the success of any business.
If you are looking for a place to buy pyrroloquinoline quinone disodium salt (PQQ) powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The pyrroloquinoline quinone disodium salt (PQQ) produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy pyrroloquinoline quinone disodium salt (PQQ) in bulk, the only place to shop is cofttek.com.
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[4]Salisbury SA, Forrest HS, Cruse WB, Kennard O (1979). "A novel coenzyme from bacterial primary alcohol dehydrogenases". Nature. 280 (5725): 843–4. doi:10.1038/280843a0. PMID 471057.
[5] Westerling J, Frank J, Duine JA (1979). "The prosthetic group of methanol dehydrogenase from Hyphomicrobium X: electron spin resonance evidence for a quinone structure". Biochem Biophys Res Commun. 87(3): 719–24. doi:10.1016/0006-291X(79)92018-7. PMID 222269.